Clinical, Research & Commercialization Collaborations

The clinical and research institutions in The Medical Capital, supported by significant federal and State of Ohio funding, namely the $2.3 Billion Third Frontier Program, have created a number of distinctive translational research and commercialization institutes:

Cleveland Brain Health Initiative

The Cleveland Brain Health Initiative based at Case Western Reserve University (CWRU) links the work of neuroscience leaders from CWRU, Cleveland Clinic, University Hospitals Cleveland Medical Center, MetroHealth Medical Center and the Louis Stokes Cleveland VA Medical Center. The goal is to advance the understanding and treatment of brain diseases, including Alzheimer’s disease, Parkinson’s disease, autism, epilepsy, schizophrenia, depression and traumatic brain injury.

Case Comprehensive Cancer Center

The Case Comprehensive Cancer Center (CCCC) based at Case Western Reserve University (CWRU) is a partnership organization supporting cancer-related research efforts at CWRU, University Hospitals Cleveland Medical Center, and Cleveland Clinic.  The Cancer Center advocates for cancer research support across the institutions; provides funding for promising pilot grants, shared resource development, training programs, and recruitment; and catalyzes cancer research across institutions, emphasizing innovative discovery for improved patient treatment.

Quick Facts and Links

Cleveland Clinical and Translational Science Collaborative

The Clinical and Translational Science Collaborative (CTSC) provides developmental, organizational, financial, and educational support to biomedical researchers while creating opportunities for community members to participate in meaningful and valuable research.

The goal of the CTSC is to provide full service and integrated clinical translational research capability within the Cleveland community that will improve the health of patients in Northeast Ohio through patient-based research. The CTSC also provides career development support for clinical investigators

Quick Facts and Links

  • Coordinates resources relevant to clinical research at CWRU and its hospital affiliates
  • Resources include three Clinical Research Unit facilities, a successful multidisciplinary institutional KL2 scholars program, substantial technological and statistical core facilities, and a M.D.-Ph.D. program in clinical research
  • About
  • Services for Researchers
  • Community
  • Pilot Programs
  • Clinical Trials

National Center for Regenerative Medicine

The National Center for Regenerative Medicine (NCRM) is a platform to facilitate translational research, clinical application, and commercialization of regenerative medicine, tissue engineering, and stem cell therapeutics across a consortium of institutions. NCRM is driven by four nationally ranked, medical research powerhouses: Case Western Reserve University, Cleveland Clinic, University Hospitals Case Medical Center and The Ohio State University. Through this network of researchers and clinicians, research discoveries are translated into cell-based therapies for patient care through cellular manufacturing and clinical trials. Global partnerships have also been established with academic institutions and biotechnology companies to further expand research and commercialization.

Quick Facts and Links

  • The first stem cell transplant in Ohio was performed at University Hospitals Case Medical Center, one of NCRM’s key affiliates
  • Some of the earliest public patents on stem cells were filed in 1982 by NCRM’s Arnold Caplan, PhD. Those patents eventually became a mainstay for the entire industry of cellular therapeutics
  • NCRM itself was initiated in 2003 with support from the State of Ohio, leading to key partnerships with affiliates and the creation of several private companies
  • About
  • Leadership
  • Partnerships
  • Research and Clinical Trials
  • Training and Education

The Harrington Project for Discovery & Development

The Harrington Project for Discovery & Development seeks to advance medicine and society by enabling inventive physician-scientists to turn their discoveries into medicines that improve human health through a unique tripartite collaboration leveraging both non-profit and for-profit organizations: the Harrington Discovery Institute, the Innovation Support Center, and BioMotiv.

Quick Facts and Links

  • Addresses a major challenge in medicine today: a lack of resources and commitment to new drug development that has created, the “Valley of Death,” in which promising research stalls. The result has been a serious decline in approved new medicines
  • Aligns not-for-profit and for-profit for the first time and creates a mission-driven commercialization entity to overcome the organizational and financial challenges blocking drug discovery and development.
  • About
  • Leadership
  • Programs and Initiatives
  • Harrington Scholars